{"id":11995,"date":"2023-01-25T15:36:01","date_gmt":"2023-01-25T15:36:01","guid":{"rendered":"https:\/\/10.81.104.155\/int\/?post_type=article&#038;p=11995"},"modified":"2023-02-22T14:35:49","modified_gmt":"2023-02-22T14:35:49","slug":"a-new-paradigm-on-aging","status":"publish","type":"article","link":"https:\/\/sponsorcontent.cnn.com\/int\/naos\/a-new-paradigm-on-aging\/","title":{"rendered":"A New Paradigm on Aging"},"content":{"rendered":"\n  <style>\n    @media (min-width: 980px) {\n      .wp-block-hero__heading { font-size: 82px !important}\n      .wp-block-hero__sub-heading { font-size: 28px !important}\n    }\n  <\/style>\n\n<article class=\"wp-block-hero break-out\">\n\n      <div class=\"wp-block-hero__background\">\n                        <img data-src=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/NAOS_main.jpg\" alt=\"\" class=\"wp-block-hero__background__image wp-block-hero__background__image--desktop lazy\">\n              \n          <\/div>\n  \n  <i class=\"wp-block-hero__overlay\" aria-hidden=\"true\"><\/i>\n\n  \n      <i\n    aria-hidden=\"true\"\n    class=\"wp-block-hero__custom-overlay\"\n    style=\"background-color:#000000;opacity:0.25\"><\/i>\n  \n  \n  <div class=\"wp-block-hero__intro-wrap container\">\n    <h1 class=\"wp-block-hero__heading\">A New Paradigm on Aging<\/h1>\n  \n          <p class=\"wp-block-hero__sub-heading\">Unlocking the Secrets of Longevity <\/p>\n      <\/div>\n\n\n  \n    <div class=\"wp-block-hero__content-by wp-block-hero__content-by--wrap container\">      \n      <ul class=\"wp-block-hero__logos\">\n                  <li class=\"wp-block-hero__item\">\n\n                          <a href=\"https:\/\/naos.com\/\" target=\"_blank\" rel=\"sponsored noopener\">\n            \n                          <img data-src=https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/logo_blanc_larger-300x60.png alt=\"\" class=\"wp-block-hero__icon lazy\">\n            \n                          <\/a>\n            \n          <\/li>\n              <\/ul>\n    <\/div>\n    \n  <\/article>\n\n\n\n<p class=\"has-text-color has-large-font-size\" style=\"color:#012737\">Acclaimed geneticist and molecular biologist Professor Miroslav Radman conducted an experiment to find the root cause of aging but what he discovered exceeded his expectations.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p>He unlocked some of the secrets of longevity within our cells.<\/p>\n\n\n\n<p>His findings may help more of us to become centenarians. More importantly, we may live more healthy lives as we age, and without age-related diseases such as diabetes, Alzheimer&#8217;s and Parkinson\u2019s.<\/p>\n\n\n\n<div class=\"wp-block-cnn-heading\"><h2 id=\"natures-brutal-solutions\" class=\"wp-block-cnn-heading__heading\"><span style=\"color:#012737\" class=\"color\">Nature\u2019s brutal solutions<\/span><\/h2><div class=\"wp-block-cnn-heading__content\"><p>Radman\u2019s work looked at the living organisms capable of withstanding extreme conditions, such as super bacteria which survive radiation exposure equivalent to 1,000 times the lethal dose for humans. He hypothesized that the same physiological changes which enabled bacteria to adapt to hostile environments could be applied to how human cells age.<\/p><p>When a super bacteria\u2019s DNA is destroyed by extreme conditions, only active, unoxidized proteins can repair the DNA. Protein protection, therefore, explains the extreme radiation resistance. An organism\u2019s survival depends on the activity of its entire complement of proteins: the proteome, discovered Radman. Applying this to age management strategies, protecting the proteome which takes care of damaged DNA is more important than protecting the DNA itself.<\/p><\/div><\/div>\n\n\n<figure class=\"wp-block-image wp-block-image--large \"><img data-src=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-100x56.jpg\" data-srcset=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1.jpg 1920w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-300x169.jpg 300w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-1024x576.jpg 1024w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-768x432.jpg 768w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-1536x864.jpg 1536w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-1247x701.jpg 1247w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-826x465.jpg 826w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-600x338.jpg 600w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-100x56.jpg 100w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-520x293.jpg 520w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/Deinococcus-radiodurans-1-260x146.jpg 260w\" width=\"1920\" height=\"1080\" alt=\"\" class=\"wp-block-image__image lazy\"><\/figure>\n\n\n<div class=\"wp-block-cnn-heading\"><h2 id=\"professor-radman-and-naos-a-shared-vision-of-aging\" class=\"wp-block-cnn-heading__heading\"><span style=\"color:#012737\" class=\"color\">Professor Radman and NAOS: a shared vision of aging<\/span><\/h2><div class=\"wp-block-cnn-heading__content\"><p>Radman is also the founder of the Mediterranean Institute for Life Sciences (MedILS). In 2006 Radman partnered with Jean-No\u00ebl Thorel, a pharmacist-biologist and founder of NAOS \u2014 a purpose-driven skincare company with a mission to create a disruptive but respectful approach to skincare, rooted in its three brands: Bioderma, Institut Esthederm, and Etat Pur.<\/p><p>The collaboration set the next step in Professor Radman\u2019s age-related research: by protecting the proteome with a shield of natural specific protective molecules, age-related damage, even inborn predisposition to disease, could be targeted.<\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-group has-background\" style=\"background-color:#f5ea62\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-cnn-heading\"><h2 id=\"protecting-the-proteome-to-preserve-the-skins-youthfulness\" class=\"wp-block-cnn-heading__heading\">Protecting the <span style=\"color:#012737\" class=\"color\">proteome to preserve the skin\u2019s youthfulness<\/span><\/h2><div class=\"wp-block-cnn-heading__content\"><p>The scientific research partnership enabled NAOS AGING SCIENCE\u2019s research teams to work on the cutaneous application of the findings.<\/p><p>NAOS follows principles of ecobiology \u2014 the art of preserving the skin ecosystem by reinforcing its natural mechanisms. They believe that rather than over-treating the skin, it must be assisted to continue to function properly and healthily. Yet again the scientists turned to super bacteria to extract the best protector of the proteome \u2014 bacterioruberins, molecules that act as an antioxidant chaperon-like shield.<\/p><p>Isabelle Benoit, NAOS Scientific Committee member, echoes the excitement about the discovery. \u201cThe proteome is a dynamic network of complementary proteins designed by centuries of evolution to allow the skin to self-repair, self-renew and maintain health and functionality throughout time and aggressive environments,\u201d she says. \u201cProtecting the proteome maintains the skin\u2019s natural balance and empowers the skin to remain the actor of its health.\u201d<\/p><\/div><\/div>\n\n\n<figure class=\"wp-block-image wp-block-image--large \"><img data-src=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-100x67.jpg\" data-srcset=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1.jpg 1920w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-300x200.jpg 300w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-1024x683.jpg 1024w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-768x512.jpg 768w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-1536x1024.jpg 1536w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-1247x831.jpg 1247w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-826x551.jpg 826w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-600x400.jpg 600w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-100x67.jpg 100w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-520x347.jpg 520w, https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/headshot-1-260x173.jpg 260w\" width=\"1920\" height=\"1280\" alt=\"\" class=\"wp-block-image__image lazy\"><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-cnn-heading\"><h2 id=\"healthy-longevity\" class=\"wp-block-cnn-heading__heading\"><span style=\"color:#012737\" class=\"color\">Healthy longevity<\/span><\/h2><div class=\"wp-block-cnn-heading__content\"><p>Other research professionals have taken interest in the role of proteins in age-related diseases. Louise Serpell, Professor of Biochemistry and a Director of Sussex Neuroscience has studied the protein misfolding and aggregation associated with Alzheimer\u2019s disease for over 20 years.<\/p><p>Alzheimer\u2019s disease is caused by the deterioration of brain function, brain atrophy and neurodegeneration. The pathological hallmarks of Alzheimer\u2019s are the accumulation of two different proteins in the brain. Professor Louise Serpell\u2019s work aims to understand how these proteins misfold and aggregate in the disease process.<\/p><p>Today Radman is enthusiastic because after four decades of academic research on the mechanisms of DNA repair and mutagenesis, he \u201cfelt a need to tackle a profound human problem that concerns everybody\u2014 the biology of aging and age-related diseases that cause up to 90% of overall mortality.\u201d<\/p><\/div><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><span style=\"color:#012737\" class=\"color\">Our biological limits are set by genes. If the project succeeds, we could live up to 120 or 130 years of age.<\/span><\/p><cite>Professor Miroslav Radman<\/cite><\/blockquote>\n\n\n\n<p>His latest project is informally known as Everybody Centenarian. \u201cAt MedILS there is a statue of DNA made of barbed wire to represent that we are slaves to our genes\u201d, he says. \u201cOur biological limits are set by genes. If the project succeeds, we could live up to 120 or 130 years of age.\u201d<\/p>\n\n\n\n<p>And the potential doesn\u2019t stop there. \u201cTo live beyond 130 years, we\u2019d have to modify our physiology, i.e., our genome,\u201d he says. The research of NAOS and Radman could prove crucial in the quest for living healthier lives for longer.<\/p>\n\n\n\n<article class=\"wp-block-cta break-out\">\n\n\n      <div class=\"wp-block-cta__background\">\n                        <img data-src=\"https:\/\/sponsorcontent.cnn.com\/int\/wp-content\/uploads\/2023\/01\/NAOS_main.jpg\" alt=\"\" class=\"wp-block-cta__background__image wp-block-cta__background__image--desktop lazy\">\n                        <\/div>\n  \n      <i\n    aria-hidden=\"true\"\n    class=\"wp-block-cta__custom-overlay\"\n    style=\"background-color:#000000;opacity:0.3\"><\/i>\n  \n  <div class=\"container\">\n\n          <h3 class=\"wp-block-cta__heading\">To learn more about NAOS science of skin aging<\/h3>\n    \n    \n    <div class=\"wp-block-cta__buttons\">\n              <a\n        href=\"https:\/\/naos.com\/\"\n        target=\"_blank\"\n        rel=\"sponsored noopener\"        class=\"button wp-block-cta__cta\">\n          click here        <\/a>\n      \n      \n    <\/div>\n  <\/div>\n<\/article>","protected":false},"featured_media":0,"template":"","class_list":["post-11995","article","type-article","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A New Paradigm on Aging - NAOS - CNN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sponsorcontent.cnn.com\/int\/naos\/a-new-paradigm-on-aging\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A New Paradigm on Aging - NAOS - CNN\" \/>\n<meta property=\"og:description\" content=\"Acclaimed geneticist and molecular biologist Professor Miroslav Radman conducted an experiment to find the root cause of aging but what he discovered exceeded his expectations. 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